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Epigenomics
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mRNA vaccine
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HiChIP: Chromatin Conformation Sequencing Technology
In situ Hi-C followed by chromatin immunoprecipitation (HiChIP) is a novel technique for analyzing chromatin conformation. It was developed by the laboratory of Howard Chang and published in Nature Methods in November 2016 [5].
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ACC-seq
Assay for Chromatin-bound Condensates by exploratory Sequencing (ACC-seq) represents a novel technological innovation developed by the Yinqing Li and Pilong Li research team at Tsinghua University (1),
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ecDNA-seq
Extrachromosomal DNA (ecDNA) denotes circular DNA molecules that exist autonomously from chromosomes.
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ATAC-seq
ATAC-seq maps chromatin accessibility by Tn5-mediated fragmentation and adapter tagging of open chromatin.
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CUT&RUN
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CUT&Tag: A Technology for Protein-DNA Interaction Studies
This kit optimizes the reagent components of the original CUT&Tag method, featuring exclusively designed elements such as a primary antibody binding enhancer and a DNA fragment release enhancer[1].
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Whole Exome Sequencing
WES is widely employed in studies of germline mutations, cancer genomics (e.g., tumor neoantigens), and other related fields.
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Hi-C(High-throughput Chromosome Conformation Capture)
High-throughput Chromosome Conformation Capture (Hi-C) enables the study of DNA interactions across the entire genome, generating high-resolution 3D chromatin structure maps and providing information on three levels: A/B compartments,
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Reduced Representation Bisulfite Sequencing (RRBS)
Reduced Representation Bisulfite Sequencing (RRBS) is an enzymatic-enrichment strategy that selectively captures promoter regions and CpG islands followed by bisulfite conversion and sequencing [3–5].
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Targeted Bisulfite Sequencing (TBS)
Targeted Bisulfite Sequencing (TBS) is a DNA methylation profiling technology that combines multiplex bisulfite-PCR capture with next-generation sequencing (NGS) at high depth [1-2].
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