Shenglin Huang, Ph.D, Prof.​

​Principal Investigator | Professor (Doctoral Supervisor)​

Work Experience​

​Principal Investigator, Institute of Biomedical Sciences, Fudan University (2020.1–Present)

​Junior Principal Investigator, Institute of Biomedical Sciences, Fudan University (2013.9–2019.12)

​Postdoctoral Fellow, Stanford University, USA (2011.6–2013.7)

​Assistant Investigator, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute (2009.7–2011.6)

Research Directions:  
The research group integrates tumor molecular biology, RNA biology, and bioinformatics to discover and study novel therapeutic/diagnostic targets in cancer. We have established relevant RNA sequencing technologies, bioinformatics methods, and databases (exLR-seq, ASJA, EV-origin, exoRBase, RJunBase), and were the first to propose and discover the prevalence of tumor-specific transcripts (TSTs) in cancers (Nat Commun, 2016; Cell Rep, 2018; Hepatology, 2019; Cancer Res, 2020; Nucleic Acids Res, 2021). We have systematically characterized the RNA components of exosomes/extracellular vesicles and their applications in cancer (Cell Res, 2015; Nucleic Acids Res, 2018&2022; Clin Chem, 2019; Gut, 2020). Current research focuses on cancer biomarkers and nucleic acid drugs (small RNAs and mRNA). To date, we have published over 60 SCI papers with an H-index of 45 and over 10,000 citations, filed three invention patents, and secured funding from the National Key R&D Program of China, National Natural Science Foundation of China, Shanghai Science and Technology Innovation Program, as well as awards including the National "Ten Thousand Talents Program" (Young Elite Scientists), Shanghai Pujiang Program, and Rising-Star Program.

Selected Publications

1.Hongyan Lai, Yuchen Li, Hena Zhang, Jia Hu, Jiatao Liao, Ying Su, Qin Li, Bing Chen, Caiping Li, Zhen Wang, Yan Li, Jialei Wang, Zhiqiang Meng^#, Zhaohui Huang^#, Shenglin Huang^#. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. Nucleic Acids Research. 2022;50(D1):D118-D128.

2.Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, Guo W^#, He X^#, Huang S^#, HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Advanced Science. 2021, 2001701.

3.Qin Li, Hongyan Lai, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu^#, Shenglin Huang^#. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Research. 2021;49(D1):D201-D211.

4.Qiupeng Zheng, Jingjing Zhao, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang^#, Xianghuo He^#, Shenglin Huang^#. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2020;71(1):259-274.

5.Yu S, Li Y, Liao Z, Wang Z, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z^#, Huang S^#, Wang P^#. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020;69(3):540-550.

6.Yuchen Li, Jingjing Zhao, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang^#, Xianghuo He^#, Shenglin Huang^#. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry. 2019;65(6):798-808.

7.Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH^#, Huang S^#, Wu J^#. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.

8.Jingjing Zhao, Qin Li, Yuchen Li, Xianghuo He, Qiupeng Zheng^#, Shenglin Huang^#. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal. 2019;17:1143-1150.

9.Guo W, Hu Z, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X^#, Huang S^#. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports. 2018; 22(8):2016-2025.

10.Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang^#. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112.

11.Qiupeng Zheng, Chunyang Bao, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He^#, Shenglin Huang^#. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

12.Yan Li, Qiupeng Zheng, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He^#, Shenglin Huang^#. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4.