Nuclear structure, paraspeckles and long non-coding RNA--Archa Fox
Michael G. Rosenfeld
Michael Rosenfeld investigates the molecular and architectural strategies responsible for integrating genome-wide transcriptional responses to diverse signaling systems, critical for physiological and behavioral processes in all vertebrates. His work has uncovered unexpected roles of enhancers as transcription units, global roles of noncoding RNAs, and regulated dynamic alterations in nuclear architecture. These enhancer-based strategies link regulated gene responses to other cellular response programs/machinery, including DNA damage/repair and inflammation, and suggest new approaches to several prevalent diseases.