研究方向 

 

1）干细胞分化、去分化的表观遗传机制； 

2）人类疾病的干细胞模型、动物模型的建立和致病机制研究。 

 

学术成就

 

2005年毕业于中国科学院植物研究所，获理学博士学位。从2005年11月出国留学，先后在美国宾夕法尼亚州立大学、美国国立卫生研究院等机构从事博士后研究工作，主要从事表观遗传及染色质组织对基因表达调控的机理研究。2011年10月加入中国科学院广州生物医药与健康研究院，建立“干细胞表观遗传调控”研究组，任课题组长、研究员、博士生导师。2012年获得中科院“百人计划”择优支持（终期评估优秀）。作为课题负责人先后承担来自国家自然科学基金、国家重点研发计划干细胞及转化研究试点专项、中科院战略性先导科技专项、广东省重大科技专项-干细胞与组织工程、广东省重大基础研究培育项目的资助；参加科技部干细胞重大科学研究计划（973）项目。近年来，相关研究成果以通讯作者或第一作者分别发表在Cell Stem Cell, Nature Communications, Genes & Development等学术刊物上。 

 

获奖及荣誉

 

2019  国家杰出青年科学基金获得者

2018 中国科学院广州教育基地“优秀研究生导师”称号

2017 中国科学院“百人计划”终期评估优秀

2016 中国科学院广州分院“优秀青年科学家”奖

2012 中国科学院“百人计划”海外引进人才择优支持

2010 美国国立卫生研究院“研究员卓越研究奖”

 

代表论文

1. Li Y, Song Y, Xu W, Li Q, Wang X, Li K,Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Scholer H.R., Sun Q*, Yao H*. R-Loops Coordinate with SOX2 in Regulating Reprogramming to Pluripotency. Science Advances 2020. (In Press).

2. Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen Y-S, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang Y-G, Yao H*. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nature Communications 2019. 10(1):1535. doi: 10.1038/s41467-019-08949-w.

3. Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Hutchins AP, Sun H, Wang H, Yao H*. PCGF5 is required for neural differentiation of embryonic stem cells. Nature Communications 2018. 9(1):1463. doi: 10.1038/s41467-018-03781-0.

4. Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H*. RNA helicase DDX5 inhibits reprogramming to pluripotency by miRNA-based repression of RYBP and its PRC1-dependent and -independent functions. Cell Stem Cell 2017. 20(4): 462-477.

5. Ping W, Hu J, Hu G, Li H, Song Y, Xia Q, Yao M, Gong S, Jiang C*, Yao H*. Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated-iPSCs. Cell Death & Disease 2018. 9(2): 187.

6. Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H, Wang H. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Research 2017. 45(15): 8785-8805.

7. Li W, Shang L, Huang K, Li J, Wang Z, Yao H*. Identification of critical base pairs required for CTCF binding in motif M1 and M2. Protein & Cell 2017. 8(7): 544-549.

8. Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell 2014. 15(5): 574-588.

9. Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G, Yao H. Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex. Journal of Biological Chemistry 2013. 288(36): 26067-26077.

10. Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G. Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta 2012. 1819(7): 644-651.

11. Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero R, Felsenfeld G. Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes & Development 2010. 24(22): 2543-2555.

12. Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y. Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression. Oncogene 2010. 29(21): 3153-3162.